Figure 2.

Somatic hypermutation (SHM) propensity correlations between the V and DJ segments for simulated (A) human and (B) mouse B-cell receptor sequences. The combination of color and shape of a data point represents a SHM propensity or the mutation frequency of nucleotide (nt) X₀ to nt X₁. The x- and y axes show the normalized mutation frequencies (e.g., P_A➔T + P_A➔C + P_A➔G = 1) for the V and DJ segments, respectively. R_corr is the Pearson correlation coefficient, while Slope is the slope of the linear regression line.