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. 2017 Jan 17;7:681. doi: 10.3389/fimmu.2016.00681

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Copyright © 2017 Lee, Khavrutskii, Wallqvist, Bavari, Cooper and Chaudhury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of somatic hypermutation (SHM) identification in real-life C57BL/6 B-cell receptor repertoires between the standard method and BRILIA. (A) Frequency distribution of SHMs per sequence predicted for all sequences in relation to their corresponding cluster’s germline sequence. (B) SHM propensity correlation returned by the standard method. Note that SHMs were determined for parent–child sequence pairs and not germline–child sequence pairs. (C) SHM propensity correlation returned by BRILIA.