Table 1.
Annotation accuracy in simulated human B-cell receptor (BCR) repertoire.
| B-cell repertoire inductive lineage and immunosequence annotator (BRILIA) | VQUEST + JA | Partis | |||||
|---|---|---|---|---|---|---|---|
| Germline 1,000 sequences | V exact match | 826 | 83% | 393 | 39% | 481 | 48% |
| D exact match | 830 | 83% | 613 | 61% | 660 | 66% | |
| J exact match | 837 | 84% | 530 | 53% | 686 | 69% | |
| VDJ exact match | 562 | 56% | 139 | 14% | 231 | 23% | |
| V degen match | 1,000 | 100% | 862 | 86% | 969 | 97% | |
| D degen match | 956 | 96% | 808 | 81% | 890 | 89% | |
| J degen match | 985 | 99% | 843 | 84% | 938 | 94% | |
| VDJ degen match | 941 | 94% | 655 | 66% | 857 | 86% | |
| Clonally expanded 6,000 sequences | V exact match | 4,045 | 67% | 1,928 | 32% | 2,442 | 41% |
| D exact match | 4,359 | 73% | 2,990 | 50% | 3,419 | 57% | |
| J exact match | 4,548 | 76% | 2,783 | 46% | 3,777 | 63% | |
| VDJ exact match | 2,291 | 38% | 508 | 8% | 936 | 16% | |
| V degen match | 5,159 | 86% | 4,570 | 76% | 5,272 | 88% | |
| D degen match | 4,979 | 83% | 3,893 | 65% | 4,575 | 76% | |
| J degen match | 5,477 | 91% | 4,546 | 76% | 5,195 | 87% | |
| VDJ degen match | 4,059 | 68% | 2,670 | 45% | 3,827 | 64% | |