Table 2.
Annotation accuracy in simulated mouse (C57BL/6) B-cell receptor (BCR) repertoire.
| B-cell repertoire inductive lineage and immunosequence annotator (BRILIA) | VQUEST + JA | ||||
|---|---|---|---|---|---|
| Germline 1,000 sequences | V exact match | 970 | 97% | 808 | 81% |
| D exact match | 796 | 80% | 382 | 38% | |
| J exact match | 965 | 97% | 558 | 56% | |
| VDJ exact match | 751 | 75% | 184 | 18% | |
| V degen match | 998 | 100% | 942 | 94% | |
| D degen match | 947 | 95% | 833 | 83% | |
| J degen match | 993 | 99% | 918 | 92% | |
| VDJ degen match | 938 | 94% | 753 | 75% | |
| Clonally expanded 6,000 sequences | V exact match | 5,271 | 88% | 4,425 | 74% |
| D exact match | 4,088 | 68% | 1,721 | 29% | |
| J exact match | 5,604 | 93% | 3,244 | 54% | |
| VDJ exact match | 3,428 | 57% | 7,65 | 13% | |
| V degen match | 5,474 | 91% | 5,214 | 87% | |
| D degen match | 4,910 | 82% | 3,878 | 65% | |
| J degen match | 5,777 | 96% | 5,275 | 88% | |
| VDJ degen match | 4,351 | 73% | 3,129 | 52% | |