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. 2016 Aug 30;95(2):169–180. doi: 10.1007/s00109-016-1466-4

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Transcriptional profiles of preterm using hierarchical clustering of differentially expressed genes based on 292 differentially regulated genes. Hierarchical clustering of differentially expressed genes of infants with and without EOI resulted in two main clusters (clusters 1 and 2). Group A genes are upregulated genes in infants with EOI and involved in neutrophil activation, T cell proliferation, hypoxia-induced signaling, and carbohydrate metabolism. Group B genes are downregulated in infants with EOI and mainly involved in NK cell activation. The group of infants with EOI could be further differentiated in a group with low expression of group A genes (EOI*) and EOI with high expression of group A genes (EOI**)