Table 2.

Univariate and multivariate analysis of prognostic factors in CACNA1B (Ca_v2.2) for 5-year overall survival.

Characteristic	Univariate analysis			Multivariate analysis
	HR	P	95% CI	HR	P	95% CI
CACNA1B (Cav2.2) expression
High versus low	2.701	<0.001	1.797 4.061	2.639	<0.001∗	1.699 4.099
Gender
Male versus female	1.530	0.020	1.070 2.188	1.230	0.339	0.804 1.882
Age (years)
≤60 versus >60	1.273	0.189	0.888 1.826
Tumor size (cm)
≤3 versus >3	2.064	<0.001	1.431 2.976	1.138	0.597	0.705 1.836
Histopathology grading
Adenocarcinoma versus squamous cell carcinoma versus othersa	0.419	<0.001	0.306 0.574	0.572	0.004∗	0.392 0.837
Lymph node metastasis
No metastasis versus metastasis	1.482	0.047	1.005 2.185	0.995	0.985	0.575 1.721
Smoking
No smoking versus smoking	2.237	0.001	1.365 3.666	2.526	0.001∗	1.440 4.430
TNM stage
Stage I versus stage II versus stage III	1.425	0.006	1.108 1.833	1.349	0.147	0.900 2.024

^∗ P < 0.05; ^aothers, adenosquamous carcinoma.