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Sliding scale of esophageal pressure-guided titration of PEEP. The table was adapted from [59]. Ventilator setting is adjusted in one column at a time to keep the partial pressure of arterial oxygen (PaO2) between 55 and 120 mmHg. Alternatively, the oxygen saturation, as measured by pulse oximeter, is kept between 88 and 98% by using the ventilator settings in one column at a time. The positive end-expiratory pressure (PEEP) is set at such a level that transpulmonary pressure during end-expiratory occlusion (PLexp) stays between 0 and 10 cmH2O and keeps transpulmonary pressure during end-inspiratory occlusion at less than 25 cmH2O.