Table 1.
Genes affected by STAT2 T387 phosphorylation in all time points of IFN‐β treatment
| Genes | WT STAT2 | T387A STAT2 | ||||
|---|---|---|---|---|---|---|
| 4 h | 8 h | 24 h | 4 h | 8 h | 24 h | |
| AIM2 | 6.01 | 14.64 | 6.21 | 16.28 | 32.59 | 15.09 |
| GBP1 | 3.76 | 13.88 | 7.00 | 9.77 | 25.11 | 8.88 |
| IFI35 | 2.74 | 6.24 | 10.17 | 4.19 | 8.56 | 13.25 |
| IFIH1 | 9.64 | 27.82 | 21.91 | 23.28 | 55.08 | 31.96 |
| IFIT2 | 35.58 | 76.20 | 33.66 | 105.96 | 161.63 | 49.25 |
| IFIT3 | 50.77 | 127.61 | 77.31 | 136.45 | 220.37 | 102.23 |
| IFITM1 | 5.19 | 14.18 | 35.10 | 6.81 | 17.67 | 43.66 |
| MASTL | 2.28 | 3.85 | 2.94 | 5.00 | 5.73 | 4.36 |
| OAS1 | 2.39 | 6.58 | 9.44 | 5.74 | 15.74 | 17.86 |
| OAS2 | 16.06 | 53.63 | 55.19 | 40.32 | 87.87 | 85.53 |
| SP110 | 3.30 | 5.76 | 4.30 | 4.43 | 8.29 | 5.78 |
| STAT1 | 3.49 | 8.96 | 11.45 | 5.91 | 11.49 | 14.52 |
| TNFSF13B | 3.20 | 7.76 | 5.68 | 6.48 | 25.12 | 10.39 |
U6A cells expressing wild‐type or T387A STAT2 were treated with IFN‐β for 0, 4, 8, or 24 h. Total RNAs were analyzed by using an Illumina HumanHT‐12 v4 Expression BeadChip array. The average signal for each probe was used to determine expression levels. Genes with average signals below 25 and detection P‐values > 0.01 in the untreated or treated cells were excluded from the analysis. Inductions of less than twofold were not scored. The number in the table is induction fold, calculated from the ratio of treated and untreated sample.