FIG. 4.

Model of S-nitrosated βC122 in the HNOX domain. The homology model containing SNO-C122 was generated from HNOX solved structure of Nostoc (66). The heme domain is shown with helices and strands. The NO is in ball mode and the heme, ligated to His 105, is indicated in sticks. Other critical residues for HNOX structure and propagation of NO signal are indicated. The image was obtained using PYMOL. This figure is reproduced from our publication by Mulsch et al. (95); copyright^© by the National Academy of Sciences for Volumes 90–105 (1993–2008). NO, nitric oxide; SNO, S-nitrosation. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars