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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mol Genet Metab. 2016 Jun 8;119(1-2):124–130. doi: 10.1016/j.ymgme.2016.06.006

Figure 4.

Figure 4

Lymphocyte infiltration of the lumbar spinal cord in MPS I dogs exhibiting hind limb weakness following human IDUA gene transfer. Representative sections of the lumbar spinal cord (A, B) and lumbar spinal nerves (C-E) are shown for the two naïve dogs (I-665 and I-666) treated with the highest dose of AAV9 expressing human IDUA. Sections were stained with H&E (A) or immunostained for human IDUA (red) and CD20 (green) (B, C), CD4 (D), or CD8 (E). Immunostained sections were counterstained with DAPI (blue) to show nuclei.