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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Clin Pharmacol. 2016 Jun 26;57(1):64–76. doi: 10.1002/jcph.775

Figure 1.

Figure 1

Schematic representation of the structural pharmacokinetic model for morphine and its glucuronides. CLMORPHINE, total morphine clearance; Q, intercompartment morphine clearance; V1, central volume of morphine; V2, peripheral volume of morphine; FMET3, fraction metabolized to morphine-3-glucuronide; FMET6, fraction metabolized to morphine-6-glucuronide; ClO, morphine clearance by routes other than glucuronidation (calculated); CLM3G, elimination clearance of morphine-3-glucuronide; CLM6G, elimination clearance of morphine-6-glucuronide; VM3G, volume of morphine-3-glucuronide (fixed); VM6G, volume of morphine-6-glucuronide (fixed).