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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Clin Pharmacol. 2016 Jun 26;57(1):64–76. doi: 10.1002/jcph.775

Figure 3.

Figure 3

Normalized prediction distribution errors (NPDE) of the final pharmacokinetic model for (A) morphine, (B) morphine-3-glucuronide, and (C) morphine-6-glucuronide. Histograms show the kernel density plot of NPDE with a normal, Gaussian distribution overlaid for comparative purposes. The distribution of NPDE versus time since first dose and birthweight are also shown. Dotted lines represent the 5% and 95% of a standard normal distribution (i.e. 90% of npde should fall between this range). Dashed line indicates loess smooth of NPDE.