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Impact of serum creatinine (Cr) on the accumulation of the morphine metabolites: (A) morphine-6-glucuroinde and (B) morphine-3-glucuroinde. Each line represents the concentration time-course of the metabolite by serum creatinine level after a 50 μg/kg loading dose followed by a continuous morphine infusion of 5 μg/kg/h in a neonate weighing 3.5kg.
