Table 1. Inhibition effects of different compounds on IAV multiplication in vitro.
| Compound | Molecular weight (Da) | Sulfate content (%) | IC50(μg/ml) | CC50(μg/ml) | SI (CC50/IC50) |
|---|---|---|---|---|---|
| KW | 536000 | 30.1 | 34.4 ± 0.7 | 2752.6 ± 10.5 | 80.0 |
| Ribavirin | 244 | — | 24.6 ± 1.5 | 762.0 ± 8.5 | 31.0 |
| Oseltamivir | 284 | — | 13.1 ± 1.9 | 1154.7 ± 18.7 | 88.1 |
| Amantadine | 151 | — | 23.8 ± 0.6 | 410.0 ± 7.1 | 17.2 |
The inhibition effects on PR8 virus (MOI = 0.1) multiplication in MDCK cells were evaluated by CPE inhibition assay. Inhibition concentration 50% (IC50): concentration required to reduce the CPE of the virus by 50% at 48 h p.i. Cytotoxic concentration 50% (CC50): concentration required to reduce cell viability by 50%. SI: Selectivity index is defined as the ratio of CC50 to IC50 (SI = CC50/IC50).