Table 2. Enrichment of VDREs in vitD-regulated genes during infection.
| Comparison | Type of regulation | DEGs (FC > 2) | DEGs with VDRE | Proportion of DEGs with VDRE | Enrichment p-values | Significance level |
|---|---|---|---|---|---|---|
| vitD on A.f.-inf | positive (UP) | 192 | 12 | 0.062 | 0.01841 | * |
| negative (DOWN) | 106 | 5 | 0.047 | 0.2504 | ns | |
| all | 298 | 17 | 0.057 | 0.01537 | * | |
| vitD on C.a.-inf | positive (UP) | 169 | 13 | 0.076 | 0.002324 | ** |
| negative (DOWN) | 90 | 0 | 0 | 0.1772 | ns | |
| all | 259 | 13 | 0.05 | 0.05959 | ns | |
| vitD on E.c.-inf | positive (UP) | 224 | 14 | 0.062 | 0.01604 | * |
| negative (DOWN) | 120 | 2 | 0.016 | 0.7758 | ns | |
| all | 344 | 16 | 0.046 | 0.1008 | ns |
Enrichment of VDREs in the 10 kB-flanking regions of DEGs was calculated using Fisher’s exact test, comparing genes differentially regulated by vitD (FC > 2, p < 0.05) to those not differentially expressed. **p ≤ 0.01, *p ≤ 0.05.