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. 2017 Jan 17;7:40777. doi: 10.1038/srep40777

Table 2. The numbers of differentially expressed intestinal inflammation-related genes in the KEGG pathway.

Category Pathway Number of DEGs in pathway Number of up-regulated DEGs Number of down-regulated DEGs
Signal transduction MAPK signaling pathway 2 1 1
TGF-β signaling pathway 3 2 1
VEGF signaling pathway 1 1 0
Jak-STAT signaling pathway 1 1 0
Calcium signaling pathway 3 0 3
Signaling molecules and interaction Cytokine-cytokine receptor interaction 10 9 1
ECM-receptor interaction 6 5 1
Cell adhesion molecules (CAMs) 9 5 4
Transport and catabolism Endocytosis 6 4 2
Cell motility Regulation of actin cytoskeleton 11 8 3
Cell communication Focal adhesion 11 9 2
Adherens junction 1 1 0
Tight junction 5 3 2
Immune system Toll-like receptor signaling pathway 3 2 1
NOD-like receptor signaling pathway 2 1 1
RIG-I-like receptor signaling pathway 1 1 0
Natural killer cell mediated cytotoxicity 4 4 0
Antigen processing and presentation 12 10 2
T cell receptor signaling pathway 1 1 0
B cell receptor signaling pathway 2 1 1
FcεRI signaling pathway 1 1 0
FcγR-mediated phagocytosis 2 2 0
Leukocyte transendothelial migration 6 4 2
Intestinal immune network for IgA production 4 2 2
Chemokine signaling pathway 9 4 5
Immune diseases Rheumatoid arthritis 11 8 3
Bacterial infectious diseases Epithelial cell signaling in Helicobacter pylori infection 5 4 1
Pathogenic Escherichia coli infection 6 4 2
Shigellosis 6 4 2
Staphylococcus aureus infection 5 3 2
Vibrio cholerae infection 6 5 1
Bacterial invasion of epithelial cells 4 3 1