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. 2016 Oct 12;42(3):757–765. doi: 10.1038/npp.2016.187

Figure 3.

Figure 3

Cocaine-induced conditioned place preference (CPP), extinction, and cocaine-primed reinstatement in OCT3-deficient and wild-type mice. Cocaine-induced CPP and extinction (a) and reinstatement in response to a low dose of cocaine (0.93 mg/kg, ip; (b)) did not significantly differ between OCT3-deficient (n=101) and wild-type mice (n=85). Data in panel (a) represent time spent in the cocaine-paired compartment (seconds; mean±SE) prior to and after conditioning and on the final day of extinction prior to reinstatement testing in wild-type and OCT3 knockout (KO) mice. Overall, cocaine-induced CPP (*P<0.05 Post-Cond vs Pre-Cond) and extinction (#P<0.05 Last Ext vs Post-Cond) were observed in both genotypes and did not differ between wild-type and OCT3 KO mice. Data in panel (b) represent reinstatement of extinguished preference (change in time spent in the cocaine-paired compartment relative to the prior extinction session; seconds; mean±SE) following saline (0 mg/kg, ip) or low-dose cocaine (0.93 mg/kg, ip) administration in wild-type (n=26 saline; n=32 cocaine) and OCT3 KO mice (n=49 saline; n=57 cocaine). Overall, 0.93 mg/kg cocaine failed to reinstate preference and preference levels during reinstatement testing did not significantly differ between wild-type and OCT3 KO mice.