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. 2016 Oct 12;42(3):757–765. doi: 10.1038/npp.2016.187

Figure 5.

Figure 5

Normetanephrine potentiates cocaine-primed reinstatement in wild-type but not OCT3-deficient mice. Data represent reinstatement of extinguished preference (change in time spent in the cocaine-paired compartment relative to the prior extinction session; seconds; mean±SE) following saline (0 mg/kg, ip) or low-dose cocaine (0.93 mg/kg, ip) administration in wild-type (a) and OCT3 KO (b) mice following pretreatment with normetanephrine (Normet; 2.5 mg/kg, ip; 40 min; wild-type n=32; KO n=40) or vehicle (wild-type n=23; KO n=17). In wild-type mice, neither 0.093 mg/kg cocaine following vehicle pretreatment nor saline injection following normetanephrine pretreatment reinstated preference. However, injection of 0.093 mg/kg cocaine did reinstate preference when it was administered following normetanephrine pretreatment (*P<0.05 vs Normet/0 mg/kg cocaine and Veh/0.093 mg/kg cocaine; Figure 4a). No significant effects cocaine or normetanephrine pretreatment were observed in OCT3 KO mice (Figure 4b).