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. 2017 Jan 5;16:1. doi: 10.1186/s12943-016-0568-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — SPAG6 and L1TD1 methylation in NSCLC patients. Comparison of SPAG6 a and L1TD1 b methylation percentages in TU and NL samples of 146 NSCLC patients with each dot representing methylation percentages in an individual sample revealed statistically significant differences (****p < 0.0001). ROC curve analyses demonstrated that the extent of SPAG6 a and L1TD1 b methylation is able to distinguish between TU and NL samples. Blue line, reference line; red line, methylation of SPAG6; AUC, area under the curve; CI, confidence interval; TU, primary tumor sample; NL, normal lung tissue sample