Table 2.
Estimated GFR (eGFR) for patients with eGFR values at baseline and month 12
| High ferritin FCM (n = 97) | Low ferritin FCM (n = 89) | Oral iron (n = 167) | |
|---|---|---|---|
| eGFR at baseline (MDRD), mL/min/1.73 m2 | |||
| Mean (SD) | 34.9 (11.3) | 32.8 (10.8) | 34.2 (12.3) |
| ≥ 60, n (%) | 1 (1.0) | 1 (1.1) | 3 (1.8) |
| 30 to <60, n (%) | 62 (63.9) | 51 (57.3) | 101 (60.5) |
| 15 to <30, n (%) | 34 (35.1) | 37 (41.6) | 60 (35.9) |
| < 15, n (%) | 0 | 0 | 3 (1.8) |
| eGFR at month 12 (MDRD), mL/min/1.73 m2 | |||
| Mean (SD) | 35.6 (13.8) | 32.1 (12.7) | 33.4 (14.5) |
| ≥ 60, n (%) | 7 (7.2) | 4 (4.5) | 7 (4.2) |
| 30 to <60, n (%) | 54 (55.7) | 40 (44.9) | 83 (49.7) |
| 15 to <30, n (%) | 32 (33.0) | 39 (43.8) | 65 (38.9) |
| < 15, n (%) | 4 (4.1) | 6 (6.7) | 12 (7.2) |
| Change from baseline to month 12, LS mean (SE) (MDRD), mL/min/1.73 m2 | 0.7 (0.9) | -0.9 (0.9) | -0.9 (0.7) |
| p value for change vs oral irona | 0.15 | 0.99 | Reference |
| Relative change from baseline to month 12, LS mean (SE) (MDRD), % | 3.1 (2.6) | -2.4 (2.7) | -2.2 (2.0) |
| p value for change vs oral irona | 0.098 | 0.95 | Reference |
| eGFR (CKD-EPI) mL/min/1.73 m2 | n = 82 | n = 68 | n = 137 |
| Mean (SD) at baseline | 33.5 (11.9) | 32.0 (11.8) | 32.5 (13.4) |
| Mean (SD) at month 12 | 34.8 (13.1) | 31.1 (13.5) | 31.0 (14.8) |
| Change, LS mean (SE), mL/min/1.73 m2 | 1.3 (1.0) | -1.2 (1.0) | -1.7 (0.7) |
| p value for change vs oral irona | 0.012 | 0.68 | Reference |
eGFR was estimated by the MDRD-4 equation [27] at the local laboratory
CI confidence interval, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), eGFR estimated GFR, FCM ferric carboxymaltose, LS least squares, MDRD Modification of Diet in Renal Disease, SE standard error
aAnalysis of covariance analysis based on least square mean values, using repeated measures