Table 2.

Scenario testing with weights applied to each criterion

Criteria	Weights applied in each scenario
	Scenario 1 (Base Case)	Scenario 2	Scenario 3
Rarity	11.1%	14.0%	10.0%
Level of research undertaken	11.1%	0.0%	20.0%
Level of effectiveness uncertainty (robustness of endpoints)	11.1%	0.0%	10.0%
Manufacturing complexity	11.1%	0.0%	0.0%
Follow up measures or Monitoring	11.1%	6.0%	15.0%
Disease severity	11.1%	30.0%	15.0%
Available alternatives (Unmet medical need)	11.1%	20.0%	10.0%
Level of impact on disease (Disease modification)	11.1%	30.0%	20.0%
Unique indication or not	11.1%	0.0%	0.0%