Table 5.
Susceptibility of isolates to quinolone drugs and mutation in QRDR
| Serotype | Zone of inhibition mm (susceptibility category) | R-pattern betalactamsa | Mutation in QRDR | ||||
|---|---|---|---|---|---|---|---|
| Na | Cip | gyrA | gyrB | parC | |||
| Cattle | Aberdeen | 19[S] | 27[I] | - | - | - | - |
| Cattle | Virchow | 20[S] | 25[I] | - | - | - | - |
| Cattle | Typhimurium PT 3 | 21[S] | 25[I] | AmpAmcCf | - | - | - |
| Cattle | Typhimurium PT 4 | 22[S] | 27[I] | AmpAmcCf | - | - | - |
| Cattle | Haifa | 21[S] | 25[I] | - | - | - | - |
| Poultry | Saintpaul | 20[S] | 31[S] | AmcCf | - | - | - |
| Cattle | Saintpaul | 17[I] | 25[I] | AmpAmcCCf | - | - | - |
| Cattle | Saintpaul | 21[S] | 27[I] | - | - | - | - |
| Poultry | Saintpaul | 20[S] | 27[I] | - | - | - | - |
| Human | V:ROUGH-O;-:- | 22[S] | 28[I] | AmpCf | - | Ser463Ala | - |
| Cattle | Mikawasima | 20[S] | 25[I] | - | - | Val423Gly + Asp459His | - |
| Cattle | Agona | 17[I] | 31[S] | - | - | - | Thr57Ser |
| Cattle | Braenderup | 17[I] | 25[I] | - | - | Val423Gly + Asp459His | Thr57Ser |
| Swine | Miami | 22[S] | 27[I] | - | - | - | Thr57Ser + Tyr83Phe |
| Poultry | Haifa | 0[R] | 25[I] | - | Ser83Tyr | - | - |
| Cattle | Virchow | 0[R] | 26(I) | AmpAmcCf | Ser83Phe | - | - |
| Cattle | Livingstone var.14+ | 0[R] | 24(I) | - | Ser83Phe | - | - |
| Cattle | I:6;7,14:-:I,w | 7[R] | 30(I) | AmpAmcCf | Ser83Phe | - | - |
| Swine | Livingstone var.14+ | 0[R] | 20[I] | - | Ser83Phe | - | - |
| Cattle | Kentucky | 0[R] | 14[R] | AmpAmcCf | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Cattle | Kentucky | 0[R] | 12[R] | AmpCf Amc | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Cattle | Kentucky | 0[R] | 11[R] | AmpCf Amc | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Cattle | Kentucky | 0[R] | 9[R] | AmpAmcCf | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Cattle | Kentucky | 0[R] | 12[R] | AmpCf Amc | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Cattle | Kentucky | 0[R] | 10[R] | AmpAmcCf | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Human | Kentucky | 0[R] | 8[R] | AmpAmcCf Fox | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Human | Kentucky | 0[R] | 10[R] | AmpCf Amc | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Poultry | Kentucky | 0[R] | 9[R] | AmpAmcCf | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
| Poultry | Kentucky | 0[R] | 11[R] | AmpAmcCf | Ser83Phe + Asp87Gly | - | Thr57Ser + Ser80Ile |
PT Phagetype, Amp Ampicillin, Amc Amoxicillin and clavulanic acid, Cf Cephalothin, Cip Ciprofloxacin, Na- Nalidixic acid, S susceptible, I intermediately resistant, R resistant
aResistance status, isolates were fully resistant to antimicrobials written in Bold and intermediately resistant to those written in italics