Table 3. Binding characteristics of the radiolabeled GHRH antagonist JV-1-42 to RL and HT human lymphomas and MDA-MB-231 human breast cancer xenografts grown in nude mice.
Tumor | Kd,* nM | Bmax,† fmol/mg membrane protein |
---|---|---|
MDA-MB-231 | N.D. | N.D. |
RL | 4.8 ± 0.7 | 406.1 ± 24.8 |
HT | 6.6 ± 0.1 | 365.2 ± 18.1 |
N.D., not detected.
Binding affinity.
Binding capacity.