Table 2.
Comparison of LAMP, smear and culture methods for the diagnosis of pulmonary tuberculosis
| Culture+ | Culture– | Se %(95% CI) | Sp %(95% CI) | PPV (%) | NPV (%) | κ | |
|---|---|---|---|---|---|---|---|
| LAMP+ | 21 | 1 | 75(56.6–87.3) | 98(89.5–99.6) | 95.5 | 87.5 | 0.77 |
| LAMP- | 7 | 49 | |||||
| Smear+ | 22 | 1 | 78.6(60.5–89.8) | 98(89.5–99.6) | 95.6 | 89.1 | 0.797 |
| Smear- | 6 | 49 | |||||
| Smear + | Smear - | ||||||
| LAMP+ | 19 | 3 | 82.6(62.9–93) | 94.5(85.2–98.1) | 86.4 | 92.9 | 0.83 |
| LAMP- | 4 | 52 | |||||
| Culture + Smear + | Culture- Smear - | ||||||
| LAMP+ | 19 | 3 | 86.4(66.7–95.3) | 94.6(85.4–98.2) | 86.4 | 94.6 | 0.82 |
| LAMP- | 3 | 53 | |||||
| Culture + Smear- | Culture-Smear+ | ||||||
| LAMP+ | 2 | 0 | 33.3(9.7–70) | 100(20.7–100) | 100 | 80 | NA |
| LAMP - | 4 | 1 | |||||
| LAMP+ Culture+ | LAMP- Culture- | ||||||
| Smear + | 19 | 4 | 90.4(71.1–97.4) | 93(83.3–97.2) | 82.6 | 96.4 | 0.82 |
| Smear- | 2 | 53 |
Se Sensitivity, Sp Specificity, PPV Positive predictive value. NPV Negative predictive value, κ Kappa value. CI confidence interval