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. 2017 Jan 17;3:16053. doi: 10.1038/celldisc.2016.53

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Dynamic model for the formation of diverse RecA nucleofilaments as stimulated by physiologically relevant ATP. First, two RecA monomers cooperatively nucleate on ssDNA; second, the nucleated RecA dimer further extends by assembling one RecA monomer on ssDNA each step to form the lightly assembled filaments; third, by same mechanism extends to form the moderately assembled filaments; and fourth, finally extends to form the saturated filaments. Due to tight regulation of the filaments by the RecA ATPase hydrolytic activity, the longer filaments will have more ATP hydrolysis and cause significant RecA dissociation, thereby, the unsaturated filaments (the lightly assembled filaments and the moderately assembled filaments) predominate and the saturated filaments are minor.