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A collaborative/hierarchical model for selection and activation of macrophages enhancers. Macrophage LDTFs, exemplified by PU.1 and C/EBPs, collaborate with each other to bind to genomic regions containing closely spaced PU.1 and C/EBP recognition motifs to establish a primed enhancer. Signal-dependent activation of NFκB (here shown as p50 and p65) leads to its binding to primed enhancers and enhancer activation, resulting in histone acetylation and production of eRNAs.
