Table 2.

Advantages and disadvantages of different MPS strategies

Strategies	Targeted sequencing	Exome sequencing	Genome sequencing
Coverage depth	++	+	+
Range of mutation:	++	+	+++
Large rearrangement,  …
Interpretation	+++	+++	+++(exon)/+(intron)
Ethical issue	+	+++	+++
or + (targeted analysis)	or + (targeted analysis)
Data re-analysis for novel disease genes	NO	YES	YES
Cost (2015)	+	++	+++