Figure 2. Foxp3 down regulation occurs in the presence of Th17 polarizing conditions.

(a) Flow cytometric assessment of WT and Mavs^−/− spleen and mesenteric LN cells at d6 p.i. with WNV, as in Fig. 1. (b) IL-6, TGFβ and IL-17 levels were measured by ELISA in serum samples taken d6 post-WNV infection. 2B represents two independent experiments total n = 23 WT/Mavs^−/−. Statistical significance was calculated using two-tailed unpaired Student’s t tests. Error bars reflect +/− SEM.