Table 4.
Comparison of test scores, CSF protein biomarkers, and miRNA –ΔΔCt values in iNPH and PS patients of Cohort at 1 before and 1 year after shunting
| iNPH | PS | p-value | |||
| before | after | before | after | ||
| shunting | shunting | shunting | shunting | p1 = iNPH before: after | |
| (n = 21) | (n = 21) | (n = 13) | (n = 13) | p2 = PS before: after | |
| MMSE | 22 | 27 | 26 | 24 | *p1 < 0.0001 |
| [19.5∼26.5] | [24.25∼28] | [20∼27] | [22.5∼26.5] | ||
| FAB | 11 [9∼13] | 12.5 [10.75∼15] | 12 [9∼14] | 11 [9∼13] | *p1 = 0.011 |
| mRS | 2 [2∼2.5] | 1 [1∼1.75] | 2 [2∼3] | 2 [2∼3] | *p1 = 0.001 |
| iNPHGS (G+C+U) | 5 [4∼6.5] | 2 [1∼3] | 5 [3.5∼6.5] | 6 [3∼7] | *p1 < 0.0001 |
| sAβPPα (ng/ml) | 157 (61) | 218 (83) | 153 (68) | 229 (161) | *p1 = 0.001 |
| *p2 = 0.008 | |||||
| Aβ42 (pg/ml) | 630 (188) | 782 (295) | 496 (192) | 731 (403) | *p1 = 0.030 |
| *p2 = 0.008 | |||||
| p-Tau (pg/ml) | 27 (9) | 65 (35) | 25 (7) | 58 (34) | *p1 < 0.0001 |
| *p2 = 0.008 | |||||
| hsa-miR-4274 | –8.9 | –9.6 | –4.6 | –7.4 | *p2 = 0.028 |
| [–10.1∼–7.8] | [–9.9∼–8.5] | [–5.2∼–2.0] | [–9.9∼–7.0] | ||
| (n = 6) | (n = 6) |
Data are shown as mean values (SD) or median values with interquartile range. *p < 0.05, significant difference (Wilcoxon’s signed rank test). Only statistically significant results are presented.