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. 2017 Jan 17;7:40674. doi: 10.1038/srep40674

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Copyright © 2017, The Author(s)

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(a) Synonymous and non-synonyous codon variation across all MBD2/3 and GATAD2A/B coiled-coil domains are plotted against the human sequences. (b) Codon selection is mapped onto the solution structure of the MBD2:GATAD2A coiled coil complex. Conserved residues are shown as sticks and color coded for codon selection. (c) Average helical propensity for the coiled-coil domains, as determined by the Agadir algorithm, is plotted for vertebrate and invertebrate MBD2/3 and GATAD2A/B orthologs.