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. Author manuscript; available in PMC: 2017 Jan 17.
Published in final edited form as: Acc Chem Res. 2015 Oct 19;48(11):2866–2874. doi: 10.1021/acs.accounts.5b00331

Figure 5.

Figure 5

Impact of the light-triggered release of drugs from erythrocyte carriers on co-incubated cells.44 (a) HeLa cells incubated (in the dark) in the presence of erythrocytes containing the Dex conjugate 18 and the Cy5 antenna 19. HeLa cells are stained for the Dex receptor, GRα, which is cytoplasmic in the absence of Dex. (b) Illumination at 650 nm releases Dex from erythrocytes, which enters HeLa cells, binds to GRα, and induces nuclear localization. (c) HeLa cells incubated (in the dark) in the presence of erythrocytes containing the Col conjugate 17 and the DyLight antenna 22. HeLa cells are stained for microtubules. (d) Illumination at 780 nm releases Col from erythrocytes, which enters HeLa cells and binds to and depolymerizes microtubules. Reproduced with permission from ref 44. Copyright 2014 John Wiley & Sons, Inc.