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. 2016 Oct 27;9(1):114–126. doi: 10.1080/19420862.2016.1249079

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© 2017 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 5. — Downmodulation of EGFR and c-Met in H1975-HGF xenograft tumors upon JNJ-61186372 treatment. Female nude mice bearing H1975-HGF lung cancer xenografts were treated with 10 mg/kg of the indicated antibodies or control on study days 1 and 4. Tumors were collected 24 hr after the second dose (day 4). Levels of total EGFR (A), c-Met (C) and ERK1 (p44) (E) and phosphorylated c-Met (pc-MET)(B), pEGFR (D), and pERK1 (p44) (F) were analyzed by Western blot. Graphs show densitometry analysis normalized to actin. # (p < 0.05) indicates statistical significant difference compared to vehicle control (Sidak's multiple comparisons test on normalized signal values).