Table 1.

Concentration of antibody (nM) to elicit 50% of maximal FcγR binding activity (IC₅₀). Data presented in mean ± SEM of 2–3 independent experiments. *Difference between JNJ-61186372 - LF and JNJ-61186372 – NF is statistically significant (p value = 0.0001).

		FcγRI	FcγRIIa	FcγRIIIa
IgG1 isotype - NF	average	8.7	1269.4	32.4
	± SEM	1.0	340.0	2.9
JNJ-61186372 - LF	average	9.2	946.4	10.0
	± SEM	1.0	119.8	0.6
JNJ-61186372 - NF	average	11.6	1082.3	38.1*
	± SEM	1.4	351.2	0.7
EGFR x inert arm - LF	average	9.3	819.6	10.0*
	± SEM	1.2	138.3	2.0
c-Met x inert arm - LF	average	8.9	1280.0	11.3
	± SEM	1.4	197.6	1.0
EGFR (LF) x c-MET (NF)	average	10.4	975.8	14.6
	± SEM	1.5	296.2	1.6
EGFR (NF) x c-MET (LF)	average	10.8	827.9	11.1
	± SEM	0.8	191.0	1.8

NF = normal levels of core fucosylation; LF = low levels of core fucosylation.