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. 2016 Oct 27;9(1):114–126. doi: 10.1080/19420862.2016.1249079

Table 2.

Fold change to multiple FcγR binding (IC50) of different antibodies to that of JNJ-61186372 – NF.

    FcγRI FcγRIIa FcγRIIIa
IgG1 isotype - NF average 1.4 1.0 1.2
  ± SEM 0.2 0.2 0.1
JNJ-61186372 - LF average 1.3 1.2 3.8
  ± SEM 0.1 0.2 0.2
JNJ-61186372 - NF average 1.0 1.1 1.0
  ± SEM 0.1 0.4 0.0
EGFR x inert arm - LF average 1.3 1.4 4.0
  ± SEM 0.2 0.2 0.8
c-Met x inert arm - LF average 1.3 0.9 3.4
  ± SEM 0.2 0.1 0.3
EGFR (LF) x c-Met (NF) average 1.1 1.2 2.7
  ± SEM 0.2 0.4 0.3
EGFR (NF) x c-Met (LF) average 1.1 1.4 3.3
  ± SEM 0.1 0.3 0.7

NF = normal levels of core fucosylation; LF = low levels of core fucosylation.