Figure 2.

(R)-BPO-27 prevents fluid accumulation in cholera toxin-treated intestinal closed loops. A) Experimental protocol (left), loop weight/length ratio (middle), and representative photos (right) of loops treated with PBS or cholera toxin without or with (R)-BPO-27 (means ± se; n = 5–8 loops per group). B) (R)-BPO-27 dose-response study for experiments as in A (means ± se; n = 4–8 loops per group). C) Efficacy of orally administered (R)-BPO-27 (5 mg/kg) administered 60 min before surgery (means ± se; n = 3–7 loops per group). One-way ANOVA with post hoc Newman-Keuls multiple comparisons test. ***P < 0.001. ns, not significant.