Figure 4.

(S)-BPO-27 does not inhibit intestinal secretion, and (R)-BPO-27 does not inhibit intestinal absorption. A) Cholera toxin and STa toxin-induced intestinal secretion study done as in Figs. 2A and 3A but with (S)-BPO-27 (inactive enantiomer, 5 mg/kg, i.p.) (means ± se; n = 4–7 loops per group). One-way ANOVA with post hoc Newman-Keuls multiple comparisons test. B) Intestinal absorption study protocol (left), loop weight/length ratios at 0 and 30 min (middle), and percent intestinal absorption (right) in PBS-injected loops (means ± se; n = 4 loops per group); Student’s t test. ns, not significant.