TABLE 1.
Serum chemistries of mice treated for 7 d with 5 mg/kg (R)-BPO-27 (or vehicle) orally once per day
| Serum parameters | Vehicle | (R)-BPO-27 | P |
|---|---|---|---|
| Total protein (g/dl) | 4.9 ± 0.1 | 4.8 ± 0.2 | >0.05 |
| Albumin (g/dl) | 2.5 ± 0.1 | 2.5 ± 0.1 | >0.05 |
| Globulin (g/dl) | 2.4 ± 0.1 | 2.3 ± 0.1 | >0.05 |
| ALT (U/L) | 41 ± 11 | 39 ± 6 | >0.05 |
| AST (U/L) | 133 ± 23 | 139 ± 28 | >0.05 |
| ALP (U/L) | 54 ± 5 | 58 ± 4 | >0.05 |
| Total bilirubin (mg/dl) | 0.2 ± 0 | 0.16 ± 0.02 | >0.05 |
| Direct bilirubin (mg/dl) | 0.04 ± 0.02 | 0.04 ± 0.02 | >0.05 |
| Glucose (mg/dl) | 197 ± 9.3 | 207 ± 3.9 | >0.05 |
| Cholesterol (mg/dl) | 140 ± 4 | 144 ± 10 | >0.05 |
| Sodium (mM) | 147 ± 0.5 | 147 ± 0.4 | >0.05 |
| Potassium (mM) | 4.9 ± 0.1 | 5.0 ± 0.1 | >0.05 |
| Chloride (mM) | 112 ± 0.8 | 111 ± 0.6 | >0.05 |
| Calcium (mg/dl) | 8.3 ± 0.1 | 8.5 ± 0.1 | >0.05 |
| Phosphorus (mg/dl) | 5.3 ± 0.5 | 5.3 ± 0.2 | >0.05 |
| BUN (mg/dl) | 18.6 ± 3.1 | 14.0 ± 1.7 | >0.05 |
| Creatinine (mg/dl) | 0.08 ± 0.05 | 0.08 ± 0.05 | >0.05 |
| Bicarbonate (mM) | 13.2 ± 0.3 | 15.4 ± 0.9 | >0.05 |
Data represent means ± se (n = 5 mice per group). Significance determined by Student’s t test. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen.