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. 2016 Dec 27;114(2):E245–E254. doi: 10.1073/pnas.1613199114

Fig. 6.

Fig. 6.

BRC1 regulation of ABA signaling in dormant buds. A working model is shown of how BRC1 regulates ABA signaling and response in buds. BRC1 and some core transcriptional regulators of the GRN (SI Appendix, Fig. S1B) are represented. Solid arrows indicate (i) direct protein–DNA interactions based on ChIP (this work) or DAP-seq data (15); (ii) protein–protein interactions (24); and (iii) known metabolic pathways (14, 28). Potential cross-regulation between HB21/40/53, ABF3, NAP, GBF3, and NAC6 is indicated by the colored dots below genes based on direct binding (15, 29) of the TF with the same color coding. Red dots, HB21/40/53 binding; green dots, GBF3 binding; purple dots, NAP/NAC6 binding; open blue circles, binding only without ABA; white inner circles, binding only with ABA. Dotted arrows indicate indirect or untested regulation, e.g., BRC1 also may promote ABA signaling via direct control of ABF3, NAP, NAC6, GBF3, and AFP3 (also see SI Appendix, Fig. S18). In addition, BRC1 controls GRNs other than the one analyzed in this work (SI Appendix, Fig. S17).