Fig. 2.
Motor disorders of GM130-nKO mice. (A) Limb clasping reflex in GM130-nKO mouse. (B) Gait of mice was assessed with footprint assay. Footprints in red and blue indicate those made by forepaws and hind paws, respectively. (C) Shorter stride lengths of GM130-nKO mice (n = 5, **P < 0.01). (D and E) Time spent on a rotarod for control and GM130-nKO mice at age 3-wk (D) and 8-wk (E). n = 7 control mice, n = 8 GM130-nKO mice; *P < 0.05, **P < 0.01. Results from four independent trials are shown. Data are presented as the mean ± SEM. (F and G) Time needed to traverse an 18-mm (F) and 11-mm (G) round wooden rod. n = 9 control mice, n = 9 GM130-nKO mice; *P < 0.05, **P < 0.01. Results from three independent trials are shown. Data are presented as the mean ± SEM.