Fig. 6.
Characterization of the effects of small molecules in CSF solutions and in a C. elegans model of Aβ42-mediated cytotoxicity. (A) Dose-dependent effects of selected molecules from set A and set B on the half-times of the aggregation reaction of Aβ42 in 66% CSF solutions. Measurements of the effects of a 10 μM solution of selected molecules from set A and set B in 0.6% DMSO on the frequency of body bends (B) and the paralysis rate (C) at day 5 of adulthood of the Aβ42-worm model. Experimental data are averaged over three separate experiments (ntot ≅ 800 worms). The efficacy of these compounds was determined based on their ability to increase the fitness of the worms with respect to untreated Aβ42 worms. Statistics were determined using one-way ANOVA against 0.6% DMSO motility: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Error bars represent the SEM. BPM, bends per minute.