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. 2016 Dec 23;114(2):E200–E208. doi: 10.1073/pnas.1615613114

Fig. S4.

Fig. S4.

Effect of set A molecules on Aβ42 aggregation. Kinetic profiles of the aggregation of a 2 μM Aβ42 solution in the absence and presence of either 1% DMSO (black) or 0.2 (red), 0.5 (cyan), 1 (blue), 2 (yellow), 3 (green), or 5 (magenta) M eq of bexarotene (A), tamibarotene (B), TTNPB (C), BMS195614 (D), Ch55 (E), SR11237 (F), and UVI3003 (G). The solid lines represent the integrated rate law for Aβ42 aggregation fitted to the experimental data. All set A molecules, the structures of which are shown in open circles, have induced significant delay in Aβ42 aggregation similar to the results obtained with the dot-blot assay (Fig. 1). (H) Relative increase in the raw data values of the ThT fluorescence intensities in the absence and presence of small molecules.