Fig. S5.

Effect of set B molecules on Aβ42 aggregation. Kinetic profiles of the aggregation of a 2 μM Aβ42 solution in the absence and presence of either 1% DMSO (black) or 0.2 (red), 0.5 (cyan), 1 (blue), 2 (yellow), and 3 (green) M eq of MM11253 (A), adapalene (B), BMS493 (C), CD1530 (D), and LE135 (E). The solid lines represent the integrated rate law for Aβ42 aggregation fitted to the experimental data. All set B molecules, the structures of which are shown in open circles, have induced significant delay in Aβ42 aggregation at substoichiometric amounts similar to the results obtained with the dot-blot assay (Fig. 1). (F) Relative increase in the raw data values of the ThT fluorescence intensities in the absence and presence of small molecules.