Fig. S6.

Aggregation reactions of different concentrations of Aβ42 in the presence of 2 M eq of BMS195614 (set A) (A) and LE135 (set B) (B) molecules. (C) Normalized rate constants as derived from the fitted curves in A and B; these results show that at different Aβ42 monomer concentrations, the decrease in the rate constants depends on the fold-excess of the small molecules. TEM images of Aβ42 amyloid fibrils at the end points of the aggregation reactions in the absence (D) or presence of 2 M eq of either BMS195614 (E) or LE135 (F) are shown.