Fig. S10.

Lack of binding of the small molecules to monomeric Aβ42 structures. (A–F) Reaction profiles in the presence of increasing molecule concentrations are not compatible with binding to the monomeric species of Aβ42 as judged from the theoretical fitting (Methods). (G–L, Top) Superimposition of the ¹H -¹⁵N HSQC spectra of 25 μM monomeric ¹⁵N-Aβ42 in the presence of either 1% DMSO (black) or a 1 M excess of all set B molecules and UVI3003 (i.e., set A). The spectra were obtained at a ¹H frequency of 700 MHz and 278 K. (G–L, Bottom) Chemical shifts (bar graph) and normalized intensity (dotted line) of 25 μM monomeric ¹H-¹⁵N-Aβ42, as derived from the spectra, are similar to the chemical shifts and normalized intensity observed for Aβ42 in the presence of 1% DMSO.