Fig. S11.
Retardation of Aβ42 aggregation in CSF. The aggregation of Aβ42 in 20 mM Hepes, 1 mM CaCl2, and 150 mM NaCl (pH 8.0) was studied using ThT fluorescence in the absence and presence of several concentrations of CSF. (A) Representative curves of the effect of 10% and 66% CSF on the aggregation kinetics of a 2 μM Aβ42 solution in the absence and presence of 1% DMSO. (B) Half-time (t1/2), the time at which the ThT fluorescence was half-way between the starting baseline and the final plateau, was extracted from each curve and normalized against the value obtained for Aβ42 alone.