Fig. S14.

Effects of representative molecules from sets A and B on Aβ42 aggregation in C. elegans. (A) Measurements of the effect of a 10 μM solution of the selected molecules in 0.6% DMSO on the frequency of body bends at days 1, 3, and 5 of adulthood of the Aβ42-worm model. The measurement of the motility at day 5 is represented with black bars and was used for Fig. 4, because it shows the most significant difference in phenotype with respect to the control-worms. Measurements of the effect of increasing concentrations of selected small molecules ranging from 1 to 10 μM on the frequency of body bends of either Aβ42-worms (B) or control-worms (C) are shown. Note that the presence of small molecules did not show any effect on the motility of the control-worms, but they induced a significant increase in the fitness of the Aβ42-worms at day 5 of adulthood in a concentration-dependent manner. Both plots show one representative dataset of three independent experiments that gave consistent results. Error bars represent the SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. BPM, bends per minute.