Fig. 1.

(Top) Introduction of a dual-germline homing gene drive construct as simulated for Namawala, Tanzania, in the 1990s, varying homing rate versus fecundity reduction. Red indicates collapse of the vector population; yellow, the absence of wild-type mosquitoes but the persistence of the population for at least 8 y after release; green, the disappearance of the gene drive construct; and black, the copresence of both wild type and introduced construct after 8 y. (Middle) One hundred trajectories for adult vector population randomly selected from the 1,000 points in the top panel, with matching color scheme. (Bottom) Corresponding 100 trajectories for fraction of mosquitoes that are wild type for the adult vector population traces plotted above.