Figure 4.

(A) OV2008 cells were exposed to 20 μM mifepristone (MF) for 48 h, or to 300 nM thapsigargin (TG) or 2 μg/ml tunicamycin (TN) for 24 h. (B) The induction of GRP78 by 20 μM MF for 24 h or 48 h followed that of ER stressors TG (300 nM) or TN (2 μg/ml) used for 24 h; the effect of MF was not mimicked by an equimolar concentration of a related steroid, dexamethasone (DEX). (C) Time‐course induction of UPR‐related proteins by 20 μM MF (MF20) or 40 μM MF (MF40) in comparison to the induction achieved by the known ER stressor TN (2 μg/ml). Results are representative of at least 2 independent experiments with a similar outcome.