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Calculated apparent dissociation constants for different binding states of WT and Y39E aSyn to 15% DOPS/25% DOPE/60% DOPC SUVs.
| Protein | All bound states KD,app (mM)a |
Extended helix KD,app (mM)a |
|---|---|---|
| WT aSyn | 3.8 ± 0.5 | 9.9 ± 1.0 |
| aSyn Y39E | 3.4 ± 0.4 | 26.0 ± 1.1 |
Apparent dissociation constants are calculated from fitting the bound fractions, calculated as described in Methods in SI from Figures 6C and D, to equation 3.
