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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Neuropharmacology. 2016 Nov 19;114:20–33. doi: 10.1016/j.neuropharm.2016.11.013

Fig. 6. Positions F636 and F637 in the GluN2A subunit interactively regulate glutamate apparent potency.

Fig. 6

A-D, Graphs plot Ip EC50 values for glutamate versus the substituent at F637 position for various mutants at position F636. Asterisks indicate that interaction free energy (ΔΔGINT) values are significantly different from zero energy (*, P < 0.05; ****, P < 0.0001). E–F, Mutant cycle analysis of glutamate Ip EC50 values in dual isoleucine and tryptophan mutations at GluN2A F636/F637. Apparent free energy values associated with the various mutations (ΔGx) are given in kcal mol−1. Values of ΔΔGINT are the means ± S. E. (*, P < 0.05; ****, P < 0.0001; ). The equation used to calculate ΔΔGINT is given in the Materials and Methods.